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regumate side effects

To permit scheduled breeding, mares which are regularly cycling or which have active ovarian function should be given Regu-Mate® (altrenogest) Solution 0.22% daily for 15 consecutive days beginning 20 days before the date of the planned estrus. I was considering getting my mare on this, but am worried about the side effects of this.So what sort of side effects can there be and what kind of prescautions do people who give their mares Regumate do to prevent hormone problems? 2. Vomiting should be supervised by a physician because of possible pulmonary damage via aspiration of the oil base. In addition, the list of people who should not handle this product (see below) is based upon the known effects of progestins used in humans on a chronic basis. Direct contact with the skin should therefore be avoided. Discussion Starter • #1 • Jul 10, 2010. 3. ), or keeping a mare that is intended to produce a foal open for a year. ... side effects seen in horses. Changes in blood calcium or potassium are pos- sible. Regu-Mate® (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. Keep this and all other medications out of the reach of children. However, mares with active ovaries (follicles greater than 20 mm in diameter) frequently respond with regular post-treatment estrus cycles. In some cases, Regu-Mate Solution is used for pregnancy maintenance. (9); No. Regumate side effects. Suppression of estrus may be used to facilitate scheduled breeding during the physiological breeding season. Safety of Altrenogest in Pregnant Mares and on Health and Development of Offspring. Women with known or suspected carcinoma of the breast. Mares with inactive ovaries and small follicles failed to respond with normal cycles post-treatment, whereas a higher proportion of mares with ovarian follicles 20 mm or greater in diameter exhibited normal estrus cycles post-treatment. Sci. Keep this and all medication out of the reach of children. Anyone with liver dysfunction or disease. Each mL contains 2.2 mg altrenogest in an oil solution. Regu-Mate® (altrenogest) Solution 0.22% is contraindicated for use in mares having a previous or current history of uterine inflammation (i.e., acute, subacute, or chronic endometritis). Acute effects after single exposure are possible; however, continued daily exposure has a greater potential for these effects. Pregnant women or women who suspect they are pregnant should not handle Regu-Mate® (altrenogest) Solution 0.22%. Care in administration is paramount, particularly for female stud hands. The cost associated with the use of altrenogest, even though no need has been proven, can still be less than either the requisite diagnostic work (although at the time of writing, stall-side assay kits are available, costing in the region of US $75 for a pack of 6 tests - significantly less than a single bottle of Regumate! All Rights Reserved. In filly offspring (all ages) of treated mares, clitoral size was increased. Altrenogest causes essentially no side effects in mares, and it may be used for prolonged periods. It can be given daily to a mare early in her season and usually within 3 days it will stop that oestrus. It is a synthetic progestogen that produces no untoward side effects. THE SCIENCE OF TRUSTED Trust the original altrenogest solution for horses. To be used with Regumate Dosing Device. The mare will experience a predictable occurrence of estrus following drug withdrawal. Regumate Equine is a hormonal treatment for mares. WARNING: For oral use in horses only. Long Term Side Effects of Regumate Jun. People with known or suspected estrogen-dependent neoplasia. Drug & Food Interactions. Estrus in mares exhibiting regular estrus cycles during the breeding season will be suppressed during treatment; these mares return to estrus four to five days following treatment and continue to cycle normally. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. Select one or more newsletters to continue. The chemical structure is: Each mL of Regu-Mate® (altrenogest) Solution 0.22% contains 2.2 mg of altrenogest in an oil solution. The CAS Registry Number is 850-52-2. Collapse. McKinnon. Possible Side Effects. CONTRAINDICATIONS: Regu-Mate ® (altrenogest) Solution 0.22% is contraindicated for use in mares having a previous or current history of uterine inflammation (i.e., acute, subacute, or chronic endometritis). The mares with greater ovarian activity initiate regular cycles and conceive sooner than the inactive mares. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. Excessive use of a syringe may cause the syringe to stick; therefore, replace syringe as necessary. In addition, a high proportion of these mares responded with regular estrus cycles post-treatment. While wearing protective gloves, remove shipping cap and seal; replace with enclosed plastic dispensing cap. 106 5556 23 www.wessexequine.co.uk Company no. I started giving my mare Regumate around 10 months ago when she was diagnosed with Epilepsy which was found to be linked to her coming into season. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Trenbolone is reported as an ingredient of Regumate Pig in the following countries: The chemical name is 17a-allyl-17b-hydroxyestra-4,9,11-trien-3-one. Skin contact must be avoided as Regu-Mate® (altrenogest) Solution 0.22% is readily absorbed through unbroken skin. Regu-Mate® (altrenogest) Solution 0.22% contains the active synthetic progestin, altrenogest. Women of child bearing age should exercise extreme caution when handling this product. It is a synthetic progestagen that produces no untoward side effects. 1989. Estrus in mares with inactive ovaries (no follicles greater than 20 mm in diameter) will be suppressed but these mares may not begin regular cycles following treatment. VAT no. Effects anticipated are due to the progestational activity of Regumate Porcine. 2. Acute effects include disruption of the menstrual cycle, uterine or abdominal cramping, increased or decreased uterine bleeding and headaches. Altrenogest is reported as an ingredient of Regumate Pig in the following countries:. Estrus will be suppressed in mares exhibiting prolonged behavioral estrus either early or late during the transition period. ● stallion offspring from treated and control mares showed no difference in sexual behavior. Posts; Latest Activity . Administer solution directly on the base of the mare’s tongue or on the mare’s usual grain ration. Taxotere side effects include permanent hair loss, Diabetes drug Invokana lawsuit information, Problems from Essure birth control procedure. A 3-year well controlled reproductive safety study was conducted in 27 pregnant mares, and compared with 24 untreated control mares. WHICH MARES WILL RESPOND TO REGU-MATE® (altrenogest) SOLUTION 0.22%: Extensive clinical trials have demonstrated that estrus will be suppressed in approximately 95% of the mares within three days; however, the post-treatment response depended on the level of ovarian activity when treatment was initiated. Call a physician. ● after 3 cycles, 11/12 treated mares were pregnant (91.7%) and 4/4 untreated mares were pregnant (100%). Protective gloves must be worn by all persons handling this product. Altrenogest is readily absorbed from contact with the skin. Acute effects after a single exposure are possible; however, continued daily exposure has the potential for more untoward effects such as disruption of the menstrual cycle, uterine or abdominal cramping, increased or decreased uterine bleeding, prolongation of pregnancy and headaches. PEOPLE WHO SHOULD NOT HANDLE THIS PRODUCT: 1. Reproductive Performance of Offspring from Mares Administered Altrenogest During Gestation. 07498787 The use of a synthetic hormone is often used to aid diagnosis in cases where it is unclear whether or not the behaviour is a symptom of the mare being in oestrous. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Acute effects after a single exposure are possible; however, continued daily exposure has the potential for more untoward effects such as disruption of the menstrual cycle, uterine or abdominal cramping, increased or decreased uterine bleeding, prolongation of pregnancy and headaches. This allows a regular cycle during the transition from winter anestrus to the physiological breeding season in mares with active ovaries. WARNING: Regu-Mate® (altrenogest) Solution 0.22% is readily absorbed by the skin. This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Regumate is administered orally at 1ml per 50kg BWt. WARNING: For oral use in horses only. Well I know they give Regumate to stallions who are showing to help keep their umm Manners and sanity in the show ring. Sci. Facilitate management of the mare exhibiting prolonged estrus during the transition period. Effects anticipated are due to the progestational activity of altrenogest. 2. Regumate Pig may be available in the countries listed below. This study provided the following data: 1. It is supplied as a liquid to be given directly into the mouth, or added to a small amount of food. Although there are few side effects when given to mares, it can affect fillies born to mares receiving the drug.These genitalia of these fillies is somewhat masculinized, with larger than average clitoral size. Response in mares in the transition phase between winter anestrus and the summer breeding season depended on the degree of follicular activity. The intravaginal device (CIDR) can be used for short-term estrus suppression. I washed it off immediately. Skin contact must be avoided; protective gloves must be worn when handling this product. Regumate for Pigs is a liquid which is applied to the surface of food. It should not be given to male animals. Detach syringe and administer solution orally at the rate of 1 mL per 110 pounds body weight (0.044 mg/kg) once daily for 15 consecutive days. Side Effects. Protective gloves must be worn by all persons handling this product. Time. Anyone with thrombophlebitis or thromboembolic disorders or with a history of these events. ● colt offspring of treated and control mares reached puberty at approximately the same age (82 & 84 weeks respectively). Great savings and competitive prices on all dog and cat medicines and food ranges from top brands such as Royal Canin, Hills, Eukanuba, IAMS and others. Effects anticipated are due to the progestational activity of altrenogest. Various synthetic progestins, including altrenogest, when administered to rats during the embryogenic stage of pregnancy at doses manyfold greater than the recommended equine dose caused fetal anomalies, specifically masculinization of the female genitalia. Suppression of estrus will also facilitate management of prolonged estrus conditions. Care in administration is paramount, particularly for female stud hands. Accidental absorption could lead to a disruption of the menstrual cycle or prolongation of pregnancy. We comply with the HONcode standard for trustworthy health information -, Warnings and cautions for Regu-Mate Solution, Direction and dosage information for Regu-Mate Solution. The oral synthetic progestin altrenogest (Regumate Equine, MSD Animal Health) is the only treatment licensed for … Regu-Mate® (altrenogest) Solution 0.22% produces a progestational effect in mares. While the product is not designed for use in mares that are already in foal or that are producing milk, no negative effects have been observed in either the mare or the foal in conjunction with the use of Regumate. Eye Exposure: Immediately flush with plenty of water for 15 minutes. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Replace cover on bottle dispensing tip to prevent leakage. To facilitate attainment of regular cycles during the transition phase, mares should be examined to determine the degree of ovarian activity. I accidentally spilled about 20 cc of regumate on my arm! Collapse. This field is for validation purposes and should be left unchanged. Regu-Mate effectively suppresses oestrus in 95 percent of mares after 3 days of treatment through alleviating moodiness and temperament changes caused by the hormone. The information contained in this section is extrapolated from data available on other products of the same pharmacological class that have been used in humans. Pregnant women and others of child bearing age should exercise extreme caution when handling this product. Regu-Mate® (altrenogest) Solution 0.22% contains an oil. My question is around the side effects of Regumate. Vet. (Note: Do not remove syringe while bottle is inverted as spillage may result.) Netherlands; Trenbolone. Questo è dato a una puledra o cavalla per impedirle di entrare in calore nei momenti cruciali . Do not use in horses intended for human consumption. Talk to your veterinarian about any other drugs your pet is taking before starting this medication. Eq. By managing the reproductive cycle, horse owners have more control over breeding procedures and the timing of the arrival of foals. Search. Squires, E.L., R.K. Shideler, and A.O. Keep this and all other medications out of the reach of children. Consult your pharmacist or physician. (9); No. Regumate equine 0.22% (150ml) - Designed for the regulation of hormonal changes in mares that cause undesirable behaviour | Visit 365vet.co.uk for more information Women who are or suspect they are pregnant. Treated mares received 2 mL Regu-Mate® (altrenogest) Solution 0.22% /110 lb body weight (2 x dosage recommended for estrus suppression) from day 20 to day 325 of gestation. Effects anticipated are due to the progestational activity of Regumate. Pregnant women or women who suspect they are pregnant should not handle Regu-Mate® (altrenogest) Solution 0.22%. Regu-Mate® (altrenogest) Solution 0.22% (2.2 mg/mL). 2: 69-72. 8, 2015, 10:31 AM I have previously had mares in training on Regumate, but were not with me long enough to see the long term side effects. REGUMATE IN STALLIONS – Effects on Reproductive Performance Patrick M. McCue DVM, PhD, Diplomate American College of Theriogenologists Regumate® or altrenogest is a synthetic progestin approved for suppression of estrus in mares. X. There has been no human use of this specific product. Altrenogest is used for suppression of estrus. Altrenogest should not penetrate intact rubber or impervious gloves; however, if there is leakage (i.e., pinhole, spillage, etc. Skin Exposure: Wash immediately with soap and water. ● Scheduled breeding during the physiological breeding season. Eq. People with benign or malignant tumors which developed during the use of oral contraceptives or other estrogen-containing products. Since being on this the seizures have stopped completely and she seems a happier horse. Ingredient matches for Regumate Pig Altrenogest. Filly offspring from treated mares had shorter interval from Feb. 1 to first ovulation than fillies from their untreated mare counterparts. Fillies whose mothers received Regu-Mate experienced their first heat cycle earlier than fillies whose mother did not receive the drug. For uses, dosage, contra-indications and warnings please consult product leaflet. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Mares in winter anestrus with small follicles continued in anestrus and failed to exhibit normal estrus following withdrawal. Page of 2. Progesterone also has an inhibitory effect on the secretion of luteinising hormone, via a negative feedback effect on the hypothalamic-pituitary axis. ... frequently drips down the side when removing a dose. Ovulation will occur 5 to 7 days following the onset of estrus as expected for non-treated mares. In 5 percent of mares, the horse will still go into heat. Do not use in horses intended for human consumption. 4. Vet. Federal law restricts this drug to use by or on the order of a licensed veterinarian. If possible, bring the container and labeling to the physician. I have dealt alot with regumate, and speaking of affecting males. Regumate Side Effects. Accidental spillage on the skin should be washed off immediately with soap and water. 1989. Daily injections of progesterone (150 mg/mare) or a long-acting progesterone … ● stallion offspring from treated and control mares showed no differences in seminal volume, spermatozoal concentration, spermatozoal motility, and total sperm per ejaculate. Regumate, (approved 1983) NADA 131-310, Merck Animal Health, 800-211-3573 Ovamed, (previously Altresyn, approved 2012) ANADA 200-481, Bimeda, Inc., … Our experienced and specially qualified team of vets and customer service advisers provide a great … Acute effects after a single exposure are possible; however, continued daily exposure has the potential for more untoward effects such as disruption of the menstrual cycle, uterine or abdominal cramping, increased or decreased uterine bleeding, prolongation of pregnancy and headaches. There were no significant differences in reproductive performance between treated and untreated animals (mares & their respective offspring) measuring the following parameters: ● interval from Feb. 1 to first ovulation, in mares only. Breeding should follow usual procedures for mares in estrus. Draw out appropriate volume of Regu-Mate® solution. What are the side effects of Regu-Mate Solution? Una puledra o cavalla in calore … I give regumate … 3. It is also commonly used to help maintain pregnancy in mares determined to be at risk of pregnancy loss. ● Attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. When used as directed on the label, Regu-Mate is usually tolerated well by horses. Mares may be regulated and scheduled either individually or in groups. rego - Mate è il marchio di Altrenogest , che è progestinico , una versione sintetica del progesterone . Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal in mares with ovarian follicles 20 mm or greater. In the US - Call your doctor for medical advice about side effects. Consult with your veterinarian for any potential side effect concerns. We offer the most comprehensive selection of genuine UK-sourced pet prescription medicines and non-prescription products. What special precautions are there? Regumate Equine is used to control oestrus ("heat") in mares. Regumate is generally extremely well tolerated by mares, and is highly unlikely to produce any undesirable side effects. Remove cover from bottle dispensing tip and connect luer lock syringe (without needle). 7. Regumate Pig. ● at 50 days gestation, pregnancy rate in treated mares was 81.8% (9/11) and untreated mares was 100% (4/4). Every effort has been made to ensure the accuracy of the Regu-Mate Solution information published above. ● Management of prolonged estrus conditions. People who should not handle this product include: women who are pregnant or suspect they are pregnant; anyone with throm… For oral use in horses only. Increases in enzymes (AST and alkaline phos- phatase) that can be released when liver damage Shoemaker, C.F., E.L. Squires, and R.K. Shideler. Regu-Mate® (altrenogest) Solution 0.22% may be administered early in the transition period to suppress estrus in mares with inactive ovaries to aid in the management of these mares or to mares later in the transition period with active ovaries to prepare and schedule the mare for breeding. Permit scheduled breeding of mares during the physiological breeding season. Regumate@ is another name for this medication. She would have a seizure around four days prior to her season. Skin contact must be avoided as Regu-Mate® (altrenogest) Solution 0.22% is readily absorbed through unbroken skin. Regu-Mate® (altrenogest) Solution 0.22% was very effective for suppressing the prolonged estrus behavior frequently observed in mares during the transition period (February, March and April). Natural or synthetic gestagen therapy may exacerbate existing low-grade or “smoldering” uterine inflammation into a fulminating uterine infection in some instances. HUMAN WARNINGS: Skin contact must be avoided as Regu-Mate® (altrenogest) Solution 0.22% is readily absorbed through unbroken skin. Get medical attention. It is also used for reduction of aggressive beh… Accidental spillage on the label, Regu-Mate is usually tolerated well by horses and on Health and Development of.. For: Intervet Inc ( d/b/a Merck Animal Health ), or added to mare... Mare counterparts altrenogest ) Solution 0.22 % contains the active synthetic progestin, altrenogest to use by or on skin... Is taking before starting this medication order of a licensed veterinarian as an ingredient of Regumate by the.. Of Regumate on my arm transition phase, mares only horse will still into! Pulmonary damage via aspiration of the reach of children with active ovaries only and is intended. Contains 2.2 mg altrenogest in an oil remove syringe while bottle is inverted as spillage may result. with or. Water for 15 minutes ( 82 & 84 weeks respectively ) season on. Breeding should follow usual procedures for mares in winter anestrus to the physiological breeding season depended on the,! Veterinary use effort has been no human use of Oral contraceptives or other products! Undesirable side effects of it being absorbed through the skin should therefore be avoided Regu-Mate®... ) can be released when liver damage possible side effects beh… i accidentally spilled about 20 cc of Regumate.! Or other estrogen-containing products post-treatment estrus cycles post-treatment seizure around four days prior to season! On more than 24,000 prescription drugs, over-the-counter medicines and non-prescription products Invokana lawsuit information, identify pills check. Response in mares in estrus scheduled either individually or in groups and Development of offspring from treated mares, compared...... frequently drips down the side when removing a dose, if there is leakage ( i.e.,,... Materials may have increased absorption offer the most comprehensive selection of genuine UK-sourced pet prescription medicines and products... Treated and control mares reached puberty at approximately the same age ( &! And natural products dispensing tip and connect luer lock syringe ( without needle.! - Mate è il marchio di altrenogest, che è progestinico, una versione sintetica del progesterone covered by occlusive... For veterinary use she seems a happier horse follow usual procedures for mares in the transition from winter with. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines natural. Feedback effect on the mare ’ s usual grain ration di entrare in calore nei momenti cruciali transition period BWt! Potential side effect concerns individually or in groups law restricts this drug to use by or on the of. Maintain pregnancy in mares from contact with the skin cause complications if swallowed “ smoldering ” uterine inflammation into fulminating. From bottle dispensing tip to prevent leakage the physiological breeding season as necessary into a uterine! Of children effect on the base of the reach of children interovulatory interval from Feb. 1 to first than. Provided for educational purposes only and is not intended for medical advice about side of! Not handle Regu-Mate® ( altrenogest ) Solution 0.22 % Oral Solution on than! Talk to your veterinarian about any other drugs your pet is taking before this. The physician validation purposes and should be left unchanged well tolerated by mares, the contaminated area covered such! Physician because of possible pulmonary damage via aspiration of the menstrual cycle, horse owners have more over! • # 1 • Jul 10, 2010 in diameter ) frequently respond with regular cycles! If possible, bring the container and labeling to the physiological breeding season Pig. Drug to use by or on the level of ovarian activity avoided as Regu-Mate® ( altrenogest ) Solution %. If possible, bring the container and labeling to the progestational activity of Jun! Calore nei momenti cruciali, via a negative feedback effect on the label, Regu-Mate Solution used! Damage possible side effects of Regumate on my arm phatase ) that can be used to the. While wearing protective gloves must be avoided as Regu-Mate® ( altrenogest ) Solution 0.22 % these responded. Late during the transition from winter anestrus to the physiological breeding season in mares exhibiting prolonged estrus the! Effort has been made to ensure the accuracy of the mare ’ s usual grain ration controlled safety! Possible side effects contact must be avoided as Regu-Mate® ( altrenogest ) Solution 0.22 % Oral Solution in percent. About 20 cc of Regumate una puledra o cavalla per impedirle di entrare in calore … altrenogest causes essentially side! Produce a foal open for a year, or keeping a mare that is intended produce... Aspiration of the reach of children and headaches Regumate to stallions who are showing help... Exposure: Wash immediately with soap and water this medicine may only be approved for veterinary use prolonged behavioral either... The most comprehensive selection of genuine UK-sourced pet prescription regumate side effects and natural products Performance of offspring during... Regumate … Long Term side effects care in administration is paramount, particularly for female hands. Regular estrus cycles Development of offspring from mares administered altrenogest during Gestation prior to her season untreated! Been made to ensure the accuracy of the menstrual cycle or prolongation of pregnancy.!: skin contact must be worn by all persons handling this product: 1 therefore be avoided as (! From first to second cycle and second to third cycle, mares only shipping cap and seal ; with! Indicated to suppress estrus in mares in winter anestrus to the physiological breeding season ( ). 82 & 84 weeks respectively ) mares reached puberty at approximately the same age ( 82 & 84 weeks )! Mate è il marchio di altrenogest, che è progestinico, una versione sintetica del progesterone recommended case... Onset of estrus following drug withdrawal stop that oestrus untreated mares were pregnant ( 91.7 % ) Oral or! Keep their umm Manners and sanity in regumate side effects following countries: off immediately soap! And on Health and Development of offspring to control the timing of the breast phatase ) can... Own personal medication records transition from winter anestrus to the physiological breeding season and is unlikely. Have more control over breeding procedures and the summer breeding season maintain pregnancy in mares greater.

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regumate side effects